Connecting teratogen-induced congenital heart defects to neural crest cells and their effect on cardiac function
نویسندگان
چکیده
منابع مشابه
Loss of microRNAs in neural crest leads to cardiovascular syndromes resembling human congenital heart defects.
OBJECTIVE Congenital heart defects represent the most common human birth defects. Even though the genetic cause of these syndromes has been linked to candidate genes, the underlying molecular mechanisms are still largely unknown. Disturbance of neural crest cell (NCC) migration into the derivatives of the pharyngeal arches and pouches can account for many of the developmental defects. The goal ...
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In the preface for his monograph on neural crest in 1950, Horstadius' wrote, "Most text-books of embryology or anatomy make only passing mention of the neural crest as the source of origin of one or two structures in the vertebrate body. Few books devote even as much as a page to this interesting structure." Although the passage of 40 years has seen a revolution in our understanding of the neur...
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ژورنال
عنوان ژورنال: Birth Defects Research Part C: Embryo Today: Reviews
سال: 2014
ISSN: 1542-975X
DOI: 10.1002/bdrc.21082